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Cronodol tablet

                      CRONODOL
                                             Disulfiram tablet 500mg

 What is alcoholism?
     Alcoholism is a state in which a person gets addicted to alcohol and can not live without consuming alcohol.

     Alcohol is a depressive agent that slows down the messaging system between the brain and body. This makes reflexes slow and the person under intoxication does not have complete command over his body movements.
   
        Addiction to alcoholism leads to many serious and permanent health hazards to both body and brain. It affects adversely on all the organisms of the body and makes them weak and inefficient. Its ill effect involves the brain also and slow down efficiency and capacity to work.
What is cronodol?
         OR
What is Disulfiram?
     Cronodol is a trusted way to shift a person away from addiction to alcoholism. The ingredient of cronodol is Disulfiram 500mg, which is a time tested and widely used drug to treat alcoholism.
What does cronodol do?
               OR
What does Disulfiram do?
   Disulfiram changes the way, the body breaks down(metabolizes) alcohol. If a person drinks alcohol while he is taking disulfiram. He will experience uncomfortable symptoms, including severe nausea, vomiting, and headache. These symptoms discourage him from drinking alcohol by making it unpleasant.
What is the pharmacological action of Disulfiram?
      Under normal metabolism, alcohol is broken down in the liver by the enzyme alcohol dehydrogenase to acetaldehyde which is then converted by the enzyme acetaldehyde dehydrogenase into a harmless acetic acid and excreted.
       Disulfiram blocks this reaction at the intermediate stage by blocking the enzyme acetaldehyde dehydrogenase.
       Acetaldehyde is one of the major causes of the symptoms of a hangover. This produces an immediate and severe negative reaction to alcohol intake and the addict is motivated to quit it.
What happens after taking Disulfiram tablet?
    Effects from disulfiram are intentionally unpleasant to help and encourage a person to remain sober and quit drinking alcohol.    The following effects produce when a person drinking alcohol :

  • Face and body flushing.
  • Throbbing in head and neck, severe headache.
  • Blurred vision 
  • First heartbeat or sweating 
  • Dry mouth, nausea, dizziness
  • weakness or breathing difficult
  • Low blood pressure
How  Disulfiram is given?
 It is a colourless or odourless tablet that is administered with food preferably in the morning. Initial treatment should begin with 500mg tablets once a day for one or two weeks. After two weeks a maintenance dose of 250mg can be given until the patient leaves the habit of drinking.

 Precaution
   Should not be given if the person has:

  • Severe heart, liver, lungs, kidney disease.
  • Serious psychological illnesses
  • Taking certain medications that contain alcohol, such as cough medicine
  • Is pregnant.



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