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D. Pharm Pharmacology & Toxicology, Drugs acting on Autonomic Nervous System(Chapter-4)

 Chapter-4

Drugs acting on Autonomic Nervous System


1. General Consideration 





Short Questions & Answers:
01. Antidote in organophosphate poisoning 
(a) Physostigmine 
(b) Pyridostigmine 
(c) Pralidoxime 
(d) Neostigmine
02. Which of the following direct-acting cholinomimetics is mainly muscarinic in action 
(a) Bethanechol 
(b) Carbachol 
(c) Acetylcholine 
(d) All of the above
03. All of the following are action of muscarinic antagonists except 
(a) Decreases gastric secretion 
(b) Prolongs A-v conduction 
(c) Decreases tracheobronchial secretions 
(d) Causes contraction of radial muscle of iris
 04. Which of the following cranical nerve does not contain parasympathetic motor (GVE) fibers 
(a) II 
(b) VI 
(c) IX 
(d) X
05. Acetylcholine is not used in clinical practice because 
(a) It is very toxic 
(b) The doses required are very high 
(c) It is very rapidly hydrolyzed 
(d) It is very costly
06. Parasympathomimetic drugs cause 
(a) Bronchodilation 
(b) Mydriasis 
(c) Bradycardia 
(d) Constipation

07. Mechanism of action of Pralidoxime is 
(a) Stimulation of Ach receptors 
(b) Inhibition of breakdown of Ach 
(c) Blockade of Ach receptors 
(d) Reactivation of ACHE enzyme
08. Neurotransmitter in parasympathetic nervous system 
(a) Adrenaline 
(b) Acetylcholine 
(c) Nor-adrenaline 
(d) All the above
09. Resting membrane potential is 
(a) -40mV 
(b) -30mV 
(c) -70mV 
(d) -50mV
10. Hyperpolarisation means.. 
(a) K* efflux & Cl influx 
(b) Na* efflux & le influx 
(c) Na* influx & efflux 
(d) All the above
11. Select the alkaloid, muscarinic agonist used in the treatment of glaucoma 
(a) Muscarinic 
(b) Arecoline 
(c) Oxotremorine 
(d) Pilocarpined

12. Anticholinesterase drug used in the treatment of alzheimer's disease 
(a) Neostigmine 
(b) Pyridostigmine 
(c) Donepezil 
(d) Ecothiopate

13. Diagnosis of myasthenia gravis is by using 
(a) Edrophonium 
(b) Neostigmine 
(c) Succinylcholine 
(d) Atropine
14. Drug used for post operative reversal of muscular paralysis 
(a) Neostignuine 
(b) Pyridostigmine 
(c) Physostigmine 
(d) D tubocurare
15. Cholinergic receptor involved in the heart rate regulation 
(a) M1 
(b) M2 
(c) M3 
(d) M4
Q.1 Which of the following drug is classified as Cholinergic agonist agent 
A. Adrenaline 
B. Dopamine 
C. Atropine 
D. Pilocarpine
Q.2 Enzyme responsible for hydrolysis of acetylcholine is: 
A. Anticholinesterase 
B. Cholinesterase 
C. Physostigmine 
D. None of the above
Q.3 An example of Reversible anticholinesterase, acting indirectly is: 
A. Tacrine 
B. Neostigmine 
C. Donepezil 
D. All
Q.4 Irreversible anticholinesterase inhibitor is: 
A. Tacrine 
B. Edrophonium 
C. Gallantamine 
D. Malathion
Q.5 The example of nerve gases include: 
A. Tabin 
B. Sarin 
C. Soman 
D. All
Q.6 Drug used in Atropine (Belladona) poisoning is: 
A. Neostigmine 
B. Physostigmine 
C. Edrophonium 
D. Carbaryl
Q.7 Drug preferred for the treatment of Mysthenia gravis is: 
A. Neostigmine 
B. Physostigmine 
C. Rivastigmine 
D. Edrophonium
Q.8 Tensilon test is performed by the drug: 
A. Neostigmine 
B. Physostigmine 
C. Edrophonium 
D. Donepezil
Q.9 Antidote of choice for both Organophosphate and Carbamate poisoning is: 
A. Physostigmine 
B. Neostigmine 
C. Atropine 
D. Edrophonium

Q.10 Cholinesterase enzyme reactivators are: 
A. Pralidoxime 
B. Obidoxime 
C. diacetylmonoxime 
D. All



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