Skip to main content

TOPIBACT OINTMENT

                             TOPIBACT

                                                   Ointment
                                  Mupirocin Ointment IP

COMPOSITION:

  Mupirocin IP..........................................2%w/w
  In the water-soluble base...................q.s

DESCRIPTION:

       Mupirocin ointment is indicated for the topical treatment of the following primary and secondary skin infection due to susceptible pathogen: primary pyoderma such as impetigo, folliculitis, furunculosis, ecthyma; secondarily infected dermatoses such as eczema, psoriasis, atopic dermatitis, herpes, epidermolysis bullosa, and infected traumatic lesions such as ulcers, minor burns, cuts, wounds, surgical incisions, and insect bites.

Prophylactically, mupirocin ointment may be used to prevent bacterial contamination in minor burns, biopsy sites, incisions, and other clean lesions. For abrasions, minor cuts and wounds the prophylactic use of mupirocin may prevent the development of infection and permit wound healing.

MECHANISM OF ACTION:

         Mupirocin is a novel antibiotic produced through fermentation of Pseudomonas Fluorescens. Mupirocin inhibits isoleucyl transfer-RNA synthetase, thereby arresting bacterial protein synthesis.
        Due to this particular mode of action and unique chemical structure, Mupirocin does not show any cross-resistance with other clinically available antibiotics. Mupirocin shows little risk of selection of resistant bacteria if used as prescribed.
      Mupirocin has bacteriostatic properties at minimum inhibitory concentrations and bactericidal properties at the higher concentration reached when applied locally.

PHARMACOKINETICS:

     Mupirocin is poorly absorbed through intact human skin. However, if it is absorbed or it is given systemically, it is metabolized to the microbiologically inactive metabolite monic acid and rapidly excreted which is excreted mainly by the kidney(90%).

ADVERSE EFFECTS:

        Burning, pain, stinging, itching, abnormal redness, dry skin, inflammation of the skin,  nausea, oozing, skin rash, swelling, tenderness.

WARNING/PRECAUTION:

       The Mupirocin ointment formulation is not suitable for ophthalmic use, intranasal use, use in conjunction with cannulae, at the site of central venous of cannulation.
        Avoid contact with eyes. If contaminated, the eyes should be thoroughly irrigated with water until the ointment residues have been removed.
      Mupirocin should not be given to patients with a history of hypersensitivity to any of its constituents.

DOSAGE:

     Apply a small amount to surface 3 times per day, reevaluate in 3-5days.

STORAGE:

      Between 15-25 degrees Celsius. Protect from light. Do not Freeze


          Made by:
                  Torque Pharmaceutical Pvt.Ltd
                                 


Labels:

Comments

Post a Comment

Popular posts from this blog

Sukhi Tablet

  Sukhi Tablet COMPOSITION: Each film coated tablet contains : Levonorgestrel IP.       0.15 my Ethinylestradiol IP.      0.03 mg Excipients.                    q.s Colour : Titanium Dioxide IP Each film coated tablet contains : Ferrous Fumarate IP:         75 mg Equivalent to Ferrous Iron:  24.375 mg. Colour: Sunset Yellow FCF, Ponceau 4R Briliant Blue FCF (IS:5346) Storage instructions:   Store at cool & dry place, Protect from light and moisture. Keep all medicines out of reach of children. What is Try Sukhi Tablet? Try Sukhi is an oral contraceptive pill. This pill is an easy, safe, effective and reversible contraceptive for a woman wanting to delay her first pregnancy or space the next child. It is the method of choice for postponing the first pregnancy. Each packet of Try Sukhi contains one month supply. Each packet has 28 tablets. The first 21 tablets a...
Post a Comment
Read more

How to Use Rectal Suppositories Properly

HOW TO USE RECTAL SUPPOSITORIES PROPERLY  1. Wash your hands  thoroughly with  soap and water. 2. If the suppository  is soft, place it in a  refrigerator for  30 minutes to  harden it before removing  the wrapper. 3. Remove the  wrapper, if  present. 4. Lubricate the suppository tip with a water-soluble lubricant such as K-Y Jelly, not petroleum jelly (Vaseline). If you do not have this lubricant, moisten your rectal area with cool tap water 5. Lie on your side with your lower leg straightened out and your upper leg bent forward toward your stomach. 6. Lift upper buttock to expose the rectal area. 7. Insert the suppository, pointed end first, with your finger until it passes the muscular sphincter of the rectum, about 1/2 to 1 inch in infants and 1 inch in adults. (If not inserted past this sphincter, the suppository may pop out.) 8. Hold...
Post a Comment
Read more

Prescription (Chapter-1) | Pharmaceutics-II

  Chapter-1                       PRESCR IPTION DEFINITION • Prescription is a written order from a registered medical practitioner or another properly licensed practitioner such as dentist, doctor, veterinarian, etc to a pharmacist to compound and dispensed a specific medication for the patient. • The prescription also contains the direction for the patients regarding the mode of administration of drugs which dispensed to him. • Thus prescription is a medium through which treatment is provided to patients by both the physician and pharmacist. • The prescriptions are generally written in the English language but Latin words or abbreviations are frequently used in order to save time. PART OF A PRESCRIPTION Prescriptions are generally written on a typical format which are usually kept as pads. A typical prescription consists of following parts:-      1. Date      2. Name, age, sex and address...
2 comments
Read more